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Wrap Up: Postdoctoral Scholars - UT Southwestern, Dallas, TX  Wrapping Up Recommended Steps For a smooth transition at the end of your postdoc training, we recommend these important steps: Meet with your PI.

Data Science Shared Resource DataScience.SR@UTSouthwestern.edu Project Request Form PI Name(s): Email: Department: Brief description of project: Is this for a grant proposal?

Equipment, Fees & Services: Quantitative Light Microscopy Core Facility - UT Southwestern, Dallas, Texas Equipment, Fees & Services In addition to microscopes, the QLMC provides access to 3 workstations for offline/online image processing and analysis.

Formulation: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas Formulation It is frequently necessary for most hydrophobic small molecules to develop a specific formulation that will allow   in vivo   delivery of the compound at suitable concentrations.

Quantitative Analysis of Select Endogenous Metabolites: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas Quantitative Analysis of Select Endogenous Metabolites The Core is able to develop analytical methods for specific endogenous metabolites of interest and to quantitate levels in various

Our objective for this proposal is to identify and chemically optimize compounds that enhance the secretion of retained mutant UMOD protein as a new therapeutic modality for treating ADTKD-UMOD.

Our research showed that urinary proteins Mucin-1 (MUC1) and Uromodulin (UMOD) upregulate TRPM6 from the luminal side of the tubule. In Umod -/- mice, we found renal Mg 2+ wasting and, in contrast to wild-type (WT) animals, impaired glucose tolerance when fed a low Mg 2+ diet.

Pricing: Next Generation Sequencing Core Lab - UT Southwestern, Dallas, Texas Pricing Pricing is based on a cost-recovery model, and will vary depending on the experiment and data requirements. For an estimate, please   vanessa.schmid@utsouthwestern.edu .

Preclinical Pharmacology Core: Service - UT Southwestern, Dallas, Texas Pricing & Services The Preclinical Pharmacology Core offers a range of services associated with preclinical drug development and pharmacokinetics on a fee-for-service or collaborative grant-funded basis.

1 Napierala Lab protocol for human skin fibroblast culture (May 2022) Necessary Reagents Reagent Company Catalog Number DMEM, high glucose Gibco/Life Technologies 11965-092 Fetal bovine serum Hyclone SH30910.03 MEM Non-essential amino acids (NEAA) Gibco/Life Technologies 11140-050